Key Publications - Nantes Center, France
- Demolombe S, Lande G, Charpentier F, Van Den Hoff M, Baro I, Guihard G, Toumaniantz G, Le Berre N, Corbier A, De Bakker J, Opthof T, Wilde AA, Moorman A, Escande D. Transgenic Mice Overexpressing Human KvLQT1 Dominant-negative Isoform. Part I: phenotypic characterization. Cardiovascular Research 50:314-27, 2001.
- Probst V, Bezzina C, Schott JJ, Remme CA, Haverkamp W, Breithardt G, Escande D, Schulze-Bahr E, Le Marech H, Wilde AAM. Genotype-phenotype relationship in Brugada syndrome : electrocardiographic features differentiate SCN5A-related patients from non SCN5A-related patients. Journal of the American College of Cardiology. 40:350-356.2002.
- Mohler PJ, Schott JJ, Anthony, Gramolini O, Dilly KW, Guatimosim S, Dubell WH, Song LS, Haurogne K, Kyndt K, Ali ME, Rogers TB, Lederer WJ, Escande D, Le Marec H, Bennett V. Mutation of ankyrin-b causes cardiac arrhythmia due to abnormal calcium homeostasis. Nature 421, 634-639, 2003
- Le Bouter S, Demolombe S, Bellocq C, Toumaniantz G, Lande G, Siavoshian S, Leger J, Baro I, Escande D, Charpentier F. Altered Thyroid Status Induces a Complex Remodeling of the Cardiac Ion Channel Transcriptome. Circulation Research 92:234-42, 2003
- Loussouarn G, Bellocq C, Park K-H, Baro I, Charpentier F, Escande D. Phosphatidylinositol-4,5-bisphosphate, PIP(2), controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K(+) channels. EMBO Journal 22:5412-542, 2003.
- Le Bouter S, El Harchi A, Marionneau C, Bellocq C, Chambellan A, Van Veen T, Bloixel C, Gavillet B, Abriel H, Le Quang K, Chevalier JC, Lande G, Leger J, Charpentier F, Escande D, Demolombe S. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation 110:3028-3035, 2004.
- Royer A, van Veen TA, Le Bouter S, Marionneau C, Griol-Charhbili V, Leoni AL, Steenman M, van Rijen HV, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JM, Grace AA, Escande D, Charpentier F. Mouse model of SCN5A-linked hereditary Lenegre's disease: age-related conduction slowing and myocardial fibrosis. Circulation 111 : 1738-46, 2005.
- Mohler PJ, Le Scouarnec S, Denjoy I, Lowe JS, Guicheney P, Caron L, Driskell IM, Schott JJ, Norris K, Leenhardt A, Kim RB, Escande D, Roden DM. Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation 115 (4):432-41, 2007
- Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S, Demolombe S. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol 582(Pt 2):675-93, 2007
- Probst V, Denjoy I, Meregalli PG, Amirault JC, Sacher F, Mansourati J, Babuty D, Villain E, Victor J, Schott JJ, Lupoglazoff JM, Mabo P, Veltmann C, Jesel L, Chevalier P, Clur SA, Haissaguerre M, Wolpert C, Le Marec H, Wilde AA. Clinical aspects and prognosis of Brugada syndrome in children. Circulation 115(15):2042-8,2007